Search Unigenes:
Smed Unigene SMU15001274 : Putative SECRETED FRIZZLED-RELATED PROTEIN

SMU15001274 is represented by 12 transcripts from 11 libraries.


Smed Unigenes are generated by clustering all available transcripts to generate a model, or Smed Unigene, representing all similar transcripts. The Smed Unigene may not accurately reflect each transcript due to biological processes such as alternative splicing.

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with ENSEMBL and SWISPROT proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms SpeciesSpecies or DBE-value
ABY85212.1secreted frizzled-related protein 1 [Schmidtea mediterranea]NCBI-nr0.0
Y73B6BL.21aCaenorhabditis elegans Protein SFRP-1 (sfrp-1) mRNA, complete cds.H.sapiens1e-43
ENSP00000266066secreted frizzled-related protein 5H.sapiens1e-38
FBpp0075484frizzledH.sapiens2e-18
SFRP5_BOVINSecreted frizzled-related protein 5 OS=Bos taurus GN=SFRP5 PE=2 SV=1Swissprot6e-41
SELECTED MOTIF SIMILARITIES
Comparison of cluster transcripts with INTERPRO. The alignments can suggest function of the cluster.

Identified MotifsDatabaseMax Score
PF01392.17|Fz|Fz domainPFAM4.7e-29
Signal peptideSIGNALP0.678
TRANSCRIPTS
Amino acid translations of transcipts were clustered and used to generate a Smed Unigene. These transcripts are those that were clustered as well as other transcripts and sequences that have homology to the transcripts of the unigene cluster.

Transcript IDView Assembly AlignmentsTranscript Collection
GAKN01020455.1
TORONTO
comp37463_c0_seq1
SXLWT
comp63361_c0_seq1
ASXLREGEN
22178_c0s1
SRG12
smedV4_13985_0_1
DD
c78626_g1_i1
SXLREGEN
Smed_1.0.15141
OX
comp68289_c0_seq1
ASXLSORT
SMEDS2F2_00001245-RA_1_542
UNIQ
KG_SFRP-1
UNIQ
isotig21043
BERLIN
Contig45920
PN
Associated Gene Ontology Terms
Gene Ontology terms are derived from the unigene transcript cluster compared to InterPro proteins. The GO terms can suggest function of the cluster.

GO:0005615
Name extracellular space
Ontology Cellular component
Synonymn
  • related: intercellular space
Definition That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

GO:0008285
Name negative regulation of cell proliferation
Ontology Biological process
Synonymn
  • exact: down regulation of cell proliferation
  • exact: down-regulation of cell proliferation
  • exact: downregulation of cell proliferation
  • narrow: inhibition of cell proliferation
Definition Any process that stops, prevents or reduces the rate or extent of cell proliferation.

GO:0017147
Name Wnt-protein binding
Ontology Molecular function
Definition Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.

GO:0030154
Name cell differentiation
Ontology Biological process
Definition The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

GO:0030178
Name negative regulation of Wnt signaling pathway
Ontology Biological process
Synonymn
  • alt_id: GO:0045810
  • exact: down regulation of Wnt receptor signaling pathway
  • exact: down regulation of frizzled signaling pathway
  • exact: down-regulation of Wnt receptor signaling pathway
  • exact: down-regulation of frizzled signaling pathway
  • exact: downregulation of Wnt receptor signaling pathway
  • exact: downregulation of frizzled signaling pathway
  • exact: negative regulation of Wnt receptor signaling pathway
  • exact: negative regulation of Wnt receptor signalling pathway
  • exact: negative regulation of Wnt-activated signaling pathway
  • exact: negative regulation of frizzled signaling pathway
  • exact: negative regulation of frizzled signalling pathway
  • narrow: inhibition of Wnt receptor signaling pathway
  • narrow: inhibition of frizzled signaling pathway
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.

GO:0035414
Name negative regulation of catenin import into nucleus
Ontology Biological process
Synonymn
  • narrow: negative regulation of catenin protein nuclear translocation
Definition Any process that decreases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus.

GO:0035567
Name non-canonical Wnt signaling pathway
Ontology Biological process
Synonymn
  • exact: beta-catenin-independent Wnt receptor signaling pathway
  • exact: non-canonical Wnt receptor signaling pathway
  • exact: non-canonical Wnt receptor signalling pathway
  • exact: non-canonical Wnt-activated signaling pathway
Definition The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.

GO:0036342
Name post-anal tail morphogenesis
Ontology Biological process
Definition The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.

GO:0043433
Name negative regulation of sequence-specific DNA binding transcription factor activity
Ontology Biological process
Synonymn
  • broad: negative regulation of transcription factor activity
  • exact: down regulation of transcription factor activity
  • exact: down-regulation of transcription factor activity
  • exact: downregulation of transcription factor activity
  • narrow: inhibition of transcription factor activity
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

GO:0043508
Name negative regulation of JUN kinase activity
Ontology Biological process
Synonymn
  • exact: down regulation of JNK activity
  • exact: down-regulation of JNK activity
  • exact: downregulation of JNK activity
  • exact: negative regulation of JUNK activity
  • narrow: inhibition of JNK activity
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.

GO:0048546
Name digestive tract morphogenesis
Ontology Biological process
Synonymn
  • alt_id: GO:0048547
  • broad: gut morphogenesis
  • exact: alimentary canal morphogenesis
  • exact: digestive tube morphogenesis
  • exact: gastrointestinal tract morphogenesis
  • narrow: intestinal morphogenesis
Definition The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.

GO:0051898
Name negative regulation of protein kinase B signaling
Ontology Biological process
Synonymn
  • exact: negative regulation of AKT signalling cascade
  • exact: negative regulation of PKB signaling cascade
  • narrow: inhibition of protein kinase B signaling cascade
  • related: down regulation of protein kinase B signaling cascade
  • related: down-regulation of protein kinase B signaling cascade
  • related: downregulation of protein kinase B signaling cascade
  • related: negative regulation of AKT signaling cascade
  • related: negative regulation of PKB signalling cascade
  • related: negative regulation of protein kinase B signaling cascade
  • related: negative regulation of protein kinase B signalling cascade
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

GO:0060028
Name convergent extension involved in axis elongation
Ontology Biological process
Definition The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.

GO:0090090
Name negative regulation of canonical Wnt signaling pathway
Ontology Biological process
Synonymn
  • exact: negative regulation of Wnt receptor signaling pathway through beta-catenin
  • exact: negative regulation of canonical Wnt receptor signaling pathway
  • exact: negative regulation of canonical Wnt receptor signalling pathway
  • exact: negative regulation of canonical Wnt-activated signaling pathway
Definition Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

GO:0090179
Name planar cell polarity pathway involved in neural tube closure
Ontology Biological process
Definition The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.

GO:2000041
Name negative regulation of planar cell polarity pathway involved in axis elongation
Ontology Biological process
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation.

GO:2000057
Name negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis
Ontology Biological process
Synonymn
  • exact: negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis
  • exact: negative regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis
  • exact: negative regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis.