Search Unigenes:
Smed Unigene SMU15006317 : Putative CAENORHABDITIS ELEGANS PROTEIN LIN-12 LIN-12 MRNA COMPLETE CDS.

SMU15006317 is represented by 16 transcripts from 10 libraries.


Smed Unigenes are generated by clustering all available transcripts to generate a model, or Smed Unigene, representing all similar transcripts. The Smed Unigene may not accurately reflect each transcript due to biological processes such as alternative splicing.

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with ENSEMBL and SWISPROT proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms SpeciesSpecies or DBE-value
NOTCH_DROMENeurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3Swissprot0.0
NOTCH_DROMENeurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3Swissprot0.0
NOTCH_DROMENeurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3Swissprot1e-164
NOTCH_DROMENeurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3Swissprot7e-157
NOTCH_DROMENeurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3Swissprot2e-117
ENSP00000256646notch 2H.sapiens0.0
FBpp0293201NotchH.sapiens0.0
FBpp0293201NotchH.sapiens0.0
ENSP00000256646notch 2H.sapiens0.0
ENSP00000256646notch 2H.sapiens0.0
KFM79899.1Neurogenic locus Notch protein, partial [Stegodyphus mimosarum]NCBI-nr0.0
KFM79899.1Neurogenic locus Notch protein, partial [Stegodyphus mimosarum]NCBI-nr0.0
KFM79899.1Neurogenic locus Notch protein, partial [Stegodyphus mimosarum]NCBI-nr7e-86
SELECTED MOTIF SIMILARITIES
Comparison of cluster transcripts with INTERPRO. The alignments can suggest function of the cluster.

Identified MotifsDatabaseMax Score
PF00008.22|EGF|EGF-like domainPFAM2.4e-115
PF12661.2|hEGF|Human growth factor-like EGFPFAM1.5e-13
PF07974.8|EGF_2|EGF-like domainPFAM2e-09
PF07645.10|EGF_CA|Calcium-binding EGF domainPFAM1.2e-09
PF13857.1|Ank_5|Ankyrin repeats (many copies)PFAM1.9e-25
PF00066.12|Notch|LNR domainPFAM1.4e-21
PF00023.25|Ank|Ankyrin repeatPFAM4.4e-32
PF13606.1|Ank_3|Ankyrin repeatPFAM7e-24
PF13637.1|Ank_4|Ankyrin repeats (many copies)PFAM7.4e-22
PF07684.7|NODP|NOTCH proteinPFAM6.7e-11
PF12796.2|Ank_2|Ankyrin repeats (3 copies)PFAM3.7e-33
Intramembrane polypeptide regionTMHMM0.55954
Signal peptideSIGNALP0.867
PF06816.8|NOD|NOTCH proteinPFAM1.4e-05
TRANSCRIPTS
Amino acid translations of transcipts were clustered and used to generate a Smed Unigene. These transcripts are those that were clustered as well as other transcripts and sequences that have homology to the transcripts of the unigene cluster.

Transcript IDView Assembly AlignmentsTranscript Collection
GAKN01014751.1
TORONTO
comp27149_c0_seq1
SXLWT
comp67694_c0_seq1
ASXLREGEN
32311_c0s1
SRG12
smedV4_7067_0_1
DD
smedV4_7067_0_2
DD
comp62253_c0_seq1
ASXLWT
Smed_1.0.02117
OX
comp80757_c0_seq1
ASXLSORT
smed005510
UNIQ
SEKG_NOTCH1_MIDDLE
UNIQ
SEKG_NOTCH1_5PRIME
UNIQ
Contig38382
PN
Contig30812
PN
Contig54205
PN
Contig41920
PN
Associated Gene Ontology Terms
Gene Ontology terms are derived from the unigene transcript cluster compared to InterPro proteins. The GO terms can suggest function of the cluster.

GO:0000122
Name negative regulation of transcription from RNA polymerase II promoter
Ontology Biological process
Synonymn
  • alt_id: GO:0010553
  • alt_id: GO:0045816
  • exact: down regulation of transcription from RNA polymerase II promoter
  • exact: down-regulation of transcription from RNA polymerase II promoter
  • exact: downregulation of transcription from RNA polymerase II promoter
  • exact: inhibition of transcription from RNA polymerase II promoter
  • exact: negative regulation of transcription from Pol II promoter
  • related: down regulation of global transcription from RNA polymerase II promoter
  • related: down-regulation of global transcription from RNA polymerase II promoter
  • related: downregulation of global transcription from RNA polymerase II promoter
  • related: inhibition of global transcription from RNA polymerase II promoter
  • related: negative regulation of gene-specific transcription from RNA polymerase II promoter
  • related: negative regulation of global transcription from Pol II promoter
  • related: negative regulation of transcription from RNA polymerase II promoter, global
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

GO:0001708
Name cell fate specification
Ontology Biological process
Definition The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.

GO:0001745
Name compound eye morphogenesis
Ontology Biological process
Synonymn
  • exact: insect-type retina morphogenesis
Definition The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.

GO:0003682
Name chromatin binding
Ontology Molecular function
Synonymn
  • broad: lamin/chromatin binding
  • narrow: nuclear membrane vesicle binding to chromatin
  • related: microtubule/chromatin interaction
Definition Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

GO:0004872
Name receptor activity
Ontology Molecular function
Synonymn
  • alt_id: GO:0019041
  • narrow: receptor guanylate cyclase activity
  • narrow: viral antireceptor activity
Definition Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

GO:0004888
Name transmembrane signaling receptor activity
Ontology Molecular function
Synonymn
  • alt_id: GO:0004926
  • broad: transmembrane receptor activity
  • exact: transmembrane signalling receptor activity
  • narrow: non G protein coupled 7TM receptor activity
  • narrow: non-G-protein coupled 7TM receptor activity
  • narrow: non-G-protein-coupled 7TM receptor activity
Definition Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

GO:0005509
Name calcium ion binding
Ontology Molecular function
Synonymn
  • related: calcium ion storage activity
Definition Interacting selectively and non-covalently with calcium ions (Ca2+).

GO:0005622
Name intracellular
Ontology Cellular component
Synonymn
  • exact: internal to cell
  • exact: protoplasm
  • related: nucleocytoplasm
  • related: protoplast
Definition The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

GO:0005634
Name nucleus
Ontology Cellular component
Synonymn
  • exact: cell nucleus
Definition A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

GO:0005654
Name nucleoplasm
Ontology Cellular component
Definition That part of the nuclear content other than the chromosomes or the nucleolus.

GO:0005737
Name cytoplasm
Ontology Cellular component
Definition All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

GO:0005768
Name endosome
Ontology Cellular component
Definition A membrane-bounded organelle to which materials ingested by endocytosis are delivered.

GO:0005788
Name endoplasmic reticulum lumen
Ontology Cellular component
Synonymn
  • alt_id: GO:0016022
  • exact: ER cisterna
  • exact: ER lumen
  • exact: cisternal lumen
  • exact: endoplasmic reticulum cisterna
Definition The volume enclosed by the membranes of the endoplasmic reticulum.

GO:0005796
Name Golgi lumen
Ontology Cellular component
Definition The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.

GO:0005829
Name cytosol
Ontology Cellular component
Definition The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

GO:0005886
Name plasma membrane
Ontology Cellular component
Synonymn
  • alt_id: GO:0005904
  • broad: juxtamembrane
  • exact: cell membrane
  • exact: cytoplasmic membrane
  • exact: plasmalemma
  • narrow: bacterial inner membrane
  • narrow: inner endospore membrane
  • narrow: plasma membrane lipid bilayer
Definition The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

GO:0005912
Name adherens junction
Ontology Cellular component
Definition A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.

GO:0006351
Name transcription, DNA-templated
Ontology Biological process
Synonymn
  • alt_id: GO:0006350
  • alt_id: GO:0061018
  • alt_id: GO:0061022
  • broad: cellular transcription
  • broad: transcription
  • exact: DNA-dependent transcription
  • exact: cellular transcription, DNA-dependent
  • exact: transcription, DNA-dependent
  • related: transcription regulator activity
Definition The cellular synthesis of RNA on a template of DNA.

GO:0007015
Name actin filament organization
Ontology Biological process
Synonymn
  • exact: actin filament organisation
  • narrow: regulation of actin filament localization
Definition A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.

GO:0007155
Name cell adhesion
Ontology Biological process
Synonymn
  • related: cell adhesion molecule activity
Definition The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

GO:0007157
Name heterophilic cell-cell adhesion
Ontology Biological process
Synonymn
  • related: agglutination
Definition The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.

GO:0007219
Name Notch signaling pathway
Ontology Biological process
Synonymn
  • alt_id: GO:0030179
  • exact: N signaling pathway
  • exact: N signalling pathway
  • exact: Notch receptor signaling pathway
  • exact: Notch receptor signalling pathway
  • exact: Notch signalling pathway
  • exact: Notch-receptor signaling pathway
  • exact: Notch-receptor signalling pathway
Definition A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

GO:0007252
Name I-kappaB phosphorylation
Ontology Biological process
Synonymn
  • exact: IKB phosphorylation
  • exact: IkappaB phosphorylation
  • exact: inhibitor of NF-kappaB phosphorylation
  • exact: inhibitor of kappaB phosphorylation
Definition The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.

GO:0007293
Name germarium-derived egg chamber formation
Ontology Biological process
Definition Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.

GO:0007297
Name ovarian follicle cell migration
Ontology Biological process
Synonymn
  • broad: follicle cell migration
Definition The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster.

GO:0007298
Name border follicle cell migration
Ontology Biological process
Synonymn
  • broad: border cell migration
Definition The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.

GO:0007314
Name oocyte anterior/posterior axis specification
Ontology Biological process
Synonymn
  • alt_id: GO:0048112
  • exact: oocyte anterior/posterior axis determination
Definition Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.

GO:0007346
Name regulation of mitotic cell cycle
Ontology Biological process
Synonymn
  • exact: control of mitotic cell cycle progression
  • exact: mitotic cell cycle control
  • exact: mitotic cell cycle modulation
  • exact: mitotic cell cycle regulation
  • exact: modulation of mitotic cell cycle progression
  • exact: regulation of mitotic cell cycle progression
  • exact: regulation of progression through mitotic cell cycle
  • related: mitotic cell cycle regulator
Definition Any process that modulates the rate or extent of progress through the mitotic cell cycle.

GO:0007391
Name dorsal closure
Ontology Biological process
Definition The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.

GO:0007398
Name ectoderm development
Ontology Biological process
Definition The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.

GO:0007400
Name neuroblast fate determination
Ontology Biological process
Synonymn
  • alt_id: GO:0007408
  • alt_id: GO:0043347
  • alt_id: GO:0043348
  • exact: neuroblast cell fate determination
  • exact: neuroblast identity determination
Definition The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.

GO:0007403
Name glial cell fate determination
Ontology Biological process
Synonymn
  • alt_id: GO:0043361
Definition The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed.

GO:0007411
Name axon guidance
Ontology Biological process
Synonymn
  • alt_id: GO:0008040
  • exact: axon pathfinding
  • narrow: axon growth cone guidance
  • related: axon chemotaxis
Definition The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.

GO:0007419
Name ventral cord development
Ontology Biological process
Definition The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.

GO:0007422
Name peripheral nervous system development
Ontology Biological process
Definition The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.

GO:0007423
Name sensory organ development
Ontology Biological process
Synonymn
  • exact: sense organ development
Definition The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.

GO:0007424
Name open tracheal system development
Ontology Biological process
Definition The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.

GO:0007440
Name foregut morphogenesis
Ontology Biological process
Definition The process in which the anatomical structures of the foregut are generated and organized.

GO:0007446
Name imaginal disc growth
Ontology Biological process
Definition The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form.

GO:0007447
Name imaginal disc pattern formation
Ontology Biological process
Definition The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form.

GO:0007450
Name dorsal/ventral pattern formation, imaginal disc
Ontology Biological process
Synonymn
  • exact: dorsal-ventral pattern formation, imaginal disc
  • exact: dorsoventral pattern formation, imaginal disc
Definition The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed.

GO:0007451
Name dorsal/ventral lineage restriction, imaginal disc
Ontology Biological process
Synonymn
  • exact: dorsal-ventral lineage restriction, imaginal disc
  • exact: dorsoventral lineage restriction, imaginal disc
Definition Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment.

GO:0007460
Name R8 cell fate commitment
Ontology Biological process
Synonymn
  • alt_id: GO:0007461
  • exact: restriction of R8 fate
Definition The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium.

GO:0007464
Name R3/R4 cell fate commitment
Ontology Biological process
Definition The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres.

GO:0007473
Name wing disc proximal/distal pattern formation
Ontology Biological process
Definition The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing.

GO:0007474
Name imaginal disc-derived wing vein specification
Ontology Biological process
Synonymn
  • exact: wing vein specification
Definition The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.

GO:0007476
Name imaginal disc-derived wing morphogenesis
Ontology Biological process
Synonymn
  • exact: wing morphogenesis
Definition The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.

GO:0007478
Name leg disc morphogenesis
Ontology Biological process
Synonymn
  • exact: leg disc metamorphosis
Definition The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura.

GO:0007498
Name mesoderm development
Ontology Biological process
Definition The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.

GO:0007519
Name skeletal muscle tissue development
Ontology Biological process
Synonymn
  • alt_id: GO:0048637
  • related: myogenesis
Definition The developmental sequence of events leading to the formation of adult muscle that occurs in the anima. In vertebrate skeletal muscle the main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.

GO:0007521
Name muscle cell fate determination
Ontology Biological process
Definition The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed.

GO:0007616
Name long-term memory
Ontology Biological process
Definition The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.

GO:0008045
Name motor neuron axon guidance
Ontology Biological process
Synonymn
  • exact: motoneuron axon guidance
  • exact: motor axon guidance
  • exact: motor axon pathfinding
Definition The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.

GO:0008284
Name positive regulation of cell proliferation
Ontology Biological process
Synonymn
  • exact: up regulation of cell proliferation
  • exact: up-regulation of cell proliferation
  • exact: upregulation of cell proliferation
  • narrow: activation of cell proliferation
  • narrow: stimulation of cell proliferation
Definition Any process that activates or increases the rate or extent of cell proliferation.

GO:0008340
Name determination of adult lifespan
Ontology Biological process
Definition The control of viability and duration in the adult phase of the life-cycle.

GO:0008347
Name glial cell migration
Ontology Biological process
Synonymn
  • alt_id: GO:0043359
  • exact: glia cell migration
Definition The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.

GO:0008356
Name asymmetric cell division
Ontology Biological process
Synonymn
  • exact: asymmetrical cell division
  • related: asymmetric cytokinesis
  • related: asymmetrical cytokinesis
Definition The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.

GO:0008407
Name chaeta morphogenesis
Ontology Biological process
Synonymn
  • narrow: bristle morphogenesis
Definition The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.

GO:0008587
Name imaginal disc-derived wing margin morphogenesis
Ontology Biological process
Synonymn
  • exact: wing margin morphogenesis
Definition The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade.

GO:0009608
Name response to symbiont
Ontology Biological process
Synonymn
  • related: response of host to symbiont
Definition Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.

GO:0009952
Name anterior/posterior pattern specification
Ontology Biological process
Synonymn
  • related: anterior/posterior pattern formation
Definition The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.

GO:0009986
Name cell surface
Ontology Cellular component
Synonymn
  • alt_id: GO:0009928
  • alt_id: GO:0009929
  • exact: cell associated
  • exact: cell bound
Definition The external part of the cell wall and/or plasma membrane.

GO:0010001
Name glial cell differentiation
Ontology Biological process
Synonymn
  • alt_id: GO:0007404
  • alt_id: GO:0043360
  • exact: glia cell differentiation
  • exact: neuroglia differentiation
Definition The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.

GO:0010629
Name negative regulation of gene expression
Ontology Biological process
Definition Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

GO:0016021
Name integral to membrane
Ontology Cellular component
Synonymn
  • related: transmembrane
Definition Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

GO:0016330
Name second mitotic wave involved in compound eye morphogenesis
Ontology Biological process
Synonymn
  • related: second mitotic wave during compound eye morphogenesis
Definition A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia.

GO:0016333
Name morphogenesis of follicular epithelium
Ontology Biological process
Definition The process in which the anatomical structures of a follicular epithelium are generated and organized.

GO:0016348
Name imaginal disc-derived leg joint morphogenesis
Ontology Biological process
Definition The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster.

GO:0022416
Name chaeta development
Ontology Biological process
Synonymn
  • narrow: bristle development
Definition The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.

GO:0030139
Name endocytic vesicle
Ontology Cellular component
Synonymn
  • exact: endocytotic transport vesicle
  • exact: endocytotic vesicle
Definition A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.

GO:0030707
Name ovarian follicle cell development
Ontology Biological process
Definition The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.

GO:0030708
Name germarium-derived female germ-line cyst encapsulation
Ontology Biological process
Definition Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster.

GO:0030713
Name ovarian follicle cell stalk formation
Ontology Biological process
Definition Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster.

GO:0030718
Name germ-line stem cell maintenance
Ontology Biological process
Definition Any process involved in preventing uncommitted germ-line stem cells from differentiating as another cell type.

GO:0030720
Name oocyte localization involved in germarium-derived egg chamber formation
Ontology Biological process
Synonymn
  • exact: establishment and maintenance of oocyte localization in egg chamber
  • exact: establishment and maintenance of oocyte position during oogenesis
  • exact: oocyte localisation involved in germarium-derived egg chamber formation
  • exact: oogenesis, establishment and maintenance of oocyte localization
  • exact: oogenesis, oocyte localization
  • narrow: oocyte positioning during oogenesis
  • related: oocyte localization during germarium-derived egg chamber formation
  • related: oocyte localization during oogenesis
Definition Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber.

GO:0030727
Name germarium-derived female germ-line cyst formation
Ontology Biological process
Synonymn
  • exact: germarium-derived female germline cyst formation
Definition Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster.

GO:0035003
Name subapical complex
Ontology Cellular component
Synonymn
  • broad: SAC
Definition The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.

GO:0035153
Name epithelial cell type specification, open tracheal system
Ontology Biological process
Synonymn
  • broad: tracheal cell type specification
  • exact: tracheal epithelial cell type specification
Definition Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions.

GO:0035155
Name negative regulation of terminal cell fate specification, open tracheal system
Ontology Biological process
Synonymn
  • exact: down regulation of terminal cell fate specification
  • exact: down-regulation of terminal cell fate specification
  • exact: downregulation of terminal cell fate specification
  • exact: negative regulation of terminal cell fate specification
  • narrow: inhibition of terminal cell fate specification
Definition Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates.

GO:0035157
Name negative regulation of fusion cell fate specification
Ontology Biological process
Synonymn
  • exact: down regulation of fusion cell fate specification
  • exact: down-regulation of fusion cell fate specification
  • exact: downregulation of fusion cell fate specification
  • narrow: inhibition of fusion cell fate specification
Definition Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates.

GO:0035162
Name embryonic hemopoiesis
Ontology Biological process
Synonymn
  • exact: embryonic haematopoiesis
  • exact: embryonic haemopoiesis
  • exact: embryonic hematopoiesis
Definition The stages of blood cell formation that take place within the embryo.

GO:0035165
Name embryonic crystal cell differentiation
Ontology Biological process
Definition The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph.

GO:0035167
Name larval lymph gland hemopoiesis
Ontology Biological process
Synonymn
  • exact: larval lymph gland haematopoiesis
  • exact: larval lymph gland haemopoiesis
  • exact: larval lymph gland hematopoiesis
Definition The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.

GO:0035170
Name lymph gland crystal cell differentiation
Ontology Biological process
Definition The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph.

GO:0035171
Name lamellocyte differentiation
Ontology Biological process
Synonymn
  • exact: lamellocyte cell differentiation
Definition The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes.

GO:0035172
Name hemocyte proliferation
Ontology Biological process
Synonymn
  • exact: arthropod blood cell proliferation
Definition The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen.

GO:0035214
Name eye-antennal disc development
Ontology Biological process
Definition Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps.

GO:0035222
Name wing disc pattern formation
Ontology Biological process
Definition The process giving rise to the pattern of cell differentiation in the wing imaginal disc.

GO:0036011
Name imaginal disc-derived leg segmentation
Ontology Biological process
Definition Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint.

GO:0036335
Name intestinal stem cell homeostasis
Ontology Biological process
Definition Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells.

GO:0040008
Name regulation of growth
Ontology Biological process
Definition Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.

GO:0042067
Name establishment of ommatidial planar polarity
Ontology Biological process
Synonymn
  • exact: establishment of ommatidial polarity
Definition The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part.

GO:0042676
Name compound eye cone cell fate commitment
Ontology Biological process
Synonymn
  • alt_id: GO:0007466
Definition The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type.

GO:0042686
Name regulation of cardioblast cell fate specification
Ontology Biological process
Definition Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.

GO:0042688
Name crystal cell differentiation
Ontology Biological process
Definition The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph.

GO:0042689
Name regulation of crystal cell differentiation
Ontology Biological process
Definition Any process that modulates the frequency, rate or extent of crystal cell differentiation.

GO:0043234
Name protein complex
Ontology Cellular component
Synonymn
  • exact: protein-protein complex
Definition Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

GO:0045316
Name negative regulation of compound eye photoreceptor development
Ontology Biological process
Synonymn
  • broad: down regulation of eye photoreceptor development
  • broad: down-regulation of eye photoreceptor development
  • broad: downregulation of eye photoreceptor development
  • broad: inhibition of eye photoreceptor development
  • broad: negative regulation of eye photoreceptor development
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development.

GO:0045463
Name R8 cell development
Ontology Biological process
Definition The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium.

GO:0045465
Name R8 cell differentiation
Ontology Biological process
Definition The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor.

GO:0045466
Name R7 cell differentiation
Ontology Biological process
Definition The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor.

GO:0045468
Name regulation of R8 cell spacing in compound eye
Ontology Biological process
Synonymn
  • exact: regulation of R8 spacing
  • related: R8 cell spacing in compound eye
Definition Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc.

GO:0045595
Name regulation of cell differentiation
Ontology Biological process
Definition Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.

GO:0045747
Name positive regulation of Notch signaling pathway
Ontology Biological process
Synonymn
  • exact: positive regulation of N signaling pathway
  • exact: positive regulation of N signalling pathway
  • exact: positive regulation of Notch signalling pathway
  • exact: up regulation of Notch signaling pathway
  • exact: up-regulation of Notch signaling pathway
  • exact: upregulation of Notch signaling pathway
  • narrow: activation of Notch signaling pathway
  • narrow: stimulation of Notch signaling pathway
Definition Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.

GO:0045944
Name positive regulation of transcription from RNA polymerase II promoter
Ontology Biological process
Synonymn
  • alt_id: GO:0010552
  • alt_id: GO:0045817
  • exact: activation of transcription from RNA polymerase II promoter
  • exact: positive regulation of transcription from Pol II promoter
  • exact: stimulation of transcription from RNA polymerase II promoter
  • exact: up regulation of transcription from RNA polymerase II promoter
  • exact: up-regulation of transcription from RNA polymerase II promoter
  • exact: upregulation of transcription from RNA polymerase II promoter
  • narrow: stimulation of global transcription from RNA polymerase II promoter
  • related: activation of global transcription from RNA polymerase II promoter
  • related: positive regulation of gene-specific transcription from RNA polymerase II promoter
  • related: positive regulation of global transcription from Pol II promoter
  • related: positive regulation of transcription from RNA polymerase II promoter, global
  • related: up regulation of global transcription from RNA polymerase II promoter
  • related: up-regulation of global transcription from RNA polymerase II promoter
  • related: upregulation of global transcription from RNA polymerase II promoter
Definition Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

GO:0046329
Name negative regulation of JNK cascade
Ontology Biological process
Synonymn
  • exact: down regulation of JNK cascade
  • exact: down-regulation of JNK cascade
  • exact: downregulation of JNK cascade
  • narrow: inhibition of JNK cascade
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.

GO:0046331
Name lateral inhibition
Ontology Biological process
Definition Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells.

GO:0046666
Name retinal cell programmed cell death
Ontology Biological process
Synonymn
  • exact: programmed cell death, retina cells
  • exact: programmed cell death, retinal cells
  • exact: retina cell programmed cell death
  • exact: retina programmed cell death
  • exact: retinal programmed cell death
Definition Programmed cell death that occurs in the developing retina.

GO:0046667
Name compound eye retinal cell programmed cell death
Ontology Biological process
Definition Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium.

GO:0046843
Name dorsal appendage formation
Ontology Biological process
Definition Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration.

GO:0048052
Name R1/R6 cell differentiation
Ontology Biological process
Definition The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster.

GO:0048190
Name wing disc dorsal/ventral pattern formation
Ontology Biological process
Synonymn
  • exact: wing disc dorsal-ventral pattern formation
  • exact: wing disc dorsoventral pattern formation
Definition The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing.

GO:0048477
Name oogenesis
Ontology Biological process
Synonymn
  • alt_id: GO:0009993
  • alt_id: GO:0048157
  • exact: ovum development
Definition The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.

GO:0048542
Name lymph gland development
Ontology Biological process
Synonymn
  • broad: haematopoietic organ development
  • broad: haemopoietic organ development
  • broad: hematopoietic organ development
  • broad: hemopoietic organ development
Definition The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.

GO:0048666
Name neuron development
Ontology Biological process
Definition The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

GO:0048749
Name compound eye development
Ontology Biological process
Synonymn
  • alt_id: GO:0007456
  • exact: insect-type retina development
Definition The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.

GO:0048803
Name imaginal disc-derived male genitalia morphogenesis
Ontology Biological process
Synonymn
  • broad: male genital morphogenesis
Definition The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc.

GO:0048863
Name stem cell differentiation
Ontology Biological process
Definition The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.

GO:0050767
Name regulation of neurogenesis
Ontology Biological process
Definition Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons.

GO:0050768
Name negative regulation of neurogenesis
Ontology Biological process
Synonymn
  • exact: down regulation of neurogenesis
  • exact: down-regulation of neurogenesis
  • exact: downregulation of neurogenesis
  • narrow: inhibition of neurogenesis
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons.

GO:0050877
Name neurological system process
Ontology Biological process
Synonymn
  • exact: neurophysiological process
  • related: pan-neural process
Definition A organ system process carried out by any of the organs or tissues of neurological system.

GO:0051489
Name regulation of filopodium assembly
Ontology Biological process
Synonymn
  • exact: regulation of filopodia biosynthesis
  • exact: regulation of filopodia formation
  • exact: regulation of filopodium formation
Definition Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

GO:0060288
Name formation of a compartment boundary
Ontology Biological process
Synonymn
  • exact: compartment boundary formation
Definition Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier.

GO:0060429
Name epithelium development
Ontology Biological process
Definition The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.

GO:0061331
Name epithelial cell proliferation involved in Malpighian tubule morphogenesis
Ontology Biological process
Definition The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule.

GO:0061382
Name Malpighian tubule tip cell differentiation
Ontology Biological process
Definition The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells.

GO:1900087
Name positive regulation of G1/S transition of mitotic cell cycle
Ontology Biological process
Synonymn
  • exact: up regulation of G1/S transition of mitotic cell cycle
  • exact: up-regulation of G1/S transition of mitotic cell cycle
  • exact: upregulation of G1/S transition of mitotic cell cycle
  • narrow: activation of G1/S transition of mitotic cell cycle
Definition Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle.