Search Unigenes:
Smed Unigene SMU15014534 : Cannot Determine

SMU15014534 is represented by 6 transcripts from 5 libraries.


Smed Unigenes are generated by clustering all available transcripts to generate a model, or Smed Unigene, representing all similar transcripts. The Smed Unigene may not accurately reflect each transcript due to biological processes such as alternative splicing.

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with ENSEMBL and SWISPROT proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms SpeciesSpecies or DBE-value
FZD8_XENLAFrizzled-8 OS=Xenopus laevis GN=fzd8 PE=1 SV=1Swissprot0.0
ENSP00000354607frizzled class receptor 5H.sapiens0.0
FBpp0074796frizzled 2H.sapiens2e-176
F27E11.3aCaenorhabditis elegans Protein CFZ-2, isoform b.H.sapiens6e-123
XP_007891677.1PREDICTED: frizzled-8 isoform X2 [Callorhinchus milii]NCBI-nr0.0
SELECTED MOTIF SIMILARITIES
Comparison of cluster transcripts with INTERPRO. The alignments can suggest function of the cluster.

Identified MotifsDatabaseMax Score
Intramembrane polypeptide regionTMHMM0.18202
PF01392.17|Fz|Fz domainPFAM9.5e-33
Cytoplasmic polypeptide regionTMHMM0.18202
Non cytoplasmic polypeptide regionTMHMM0.18202
Signal peptideSIGNALP0.738
PF01534.12|Frizzled|Frizzled/Smoothened family membrane regionPFAM1.5e-120
TRANSCRIPTS
Amino acid translations of transcipts were clustered and used to generate a Smed Unigene. These transcripts are those that were clustered as well as other transcripts and sequences that have homology to the transcripts of the unigene cluster.

Transcript IDView Assembly AlignmentsTranscript Collection
GAKN01020288.1
TORONTO
comp74012_c0_seq2
ASXLSORT
SMEDS2F2_00029031-RA
UNIQ
Contig10439
PN
Contig40569
PN
CUFF.285936.1
BERLIN
Associated Gene Ontology Terms
Gene Ontology terms are derived from the unigene transcript cluster compared to InterPro proteins. The GO terms can suggest function of the cluster.

GO:0004930
Name G-protein coupled receptor activity
Ontology Molecular function
Synonymn
  • alt_id: GO:0001622
  • alt_id: GO:0001623
  • alt_id: GO:0001624
  • alt_id: GO:0001625
  • alt_id: GO:0016526
  • exact: G protein coupled receptor activity
  • exact: G protein linked receptor activity
  • exact: G-protein linked receptor activity
  • exact: G-protein-coupled receptor activity
  • exact: GPCR activity
  • exact: ligand-dependent GPCR activity
  • exact: receptor activity, G-protein coupled
  • narrow: EBV-induced receptor
  • narrow: Epstein-Barr Virus-induced receptor activity
  • narrow: G-protein coupled receptor activity, unknown ligand
  • narrow: Mas proto-oncogene receptor activity
  • narrow: RDC1 receptor activity
  • narrow: SREB receptor
  • narrow: orphan G protein coupled receptor activity
  • narrow: orphan G-protein coupled receptor activity
  • narrow: orphan GPCR activity
  • narrow: super conserved receptor expressed in brain receptor activity
Definition Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

GO:0005886
Name plasma membrane
Ontology Cellular component
Synonymn
  • alt_id: GO:0005904
  • broad: juxtamembrane
  • exact: cell membrane
  • exact: cytoplasmic membrane
  • exact: plasmalemma
  • narrow: bacterial inner membrane
  • narrow: inner endospore membrane
  • narrow: plasma membrane lipid bilayer
Definition The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

GO:0007275
Name multicellular organismal development
Ontology Biological process
Definition The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

GO:0016021
Name integral to membrane
Ontology Cellular component
Synonymn
  • related: transmembrane
Definition Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

GO:0051091
Name positive regulation of sequence-specific DNA binding transcription factor activity
Ontology Biological process
Synonymn
  • broad: positive regulation of transcription factor activity
  • exact: up regulation of transcription factor activity
  • exact: up-regulation of transcription factor activity
  • exact: upregulation of transcription factor activity
  • narrow: activation of transcription factor activity
  • narrow: stimulation of transcription factor activity
Definition Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

GO:0060070
Name canonical Wnt signaling pathway
Ontology Biological process
Synonymn
  • exact: Wnt receptor signaling pathway through beta-catenin
  • exact: Wnt receptor signaling pathway via beta-catenin
  • exact: Wnt receptor signalling pathway through beta-catenin
  • exact: canonical Wnt receptor signaling pathway
  • exact: canonical Wnt-activated signaling pathway
  • narrow: frizzled-1 receptor signaling pathway
Definition The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.