Search Unigenes:
Smed Unigene SMU15026192 : Putative NOTCH 2

Smed Unigenes are generated by clustering all available transcripts to generate a model, or Smed Unigene, representing all similar transcripts. The Smed Unigene may not accurately reflect each transcript due to biological processes such as alternative splicing.

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with ENSEMBL and SWISPROT proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms SpeciesSpecies or DBE-value
CDI99319.1notch [Echinococcus multilocularis]NCBI-nr3e-73
NOTC1_CRIGRNeurogenic locus notch homolog protein 1 OS=Cricetulus griseus GN=NOTCH1 PE=1 SV=2Swissprot4e-62
NOTC1_CRIGRNeurogenic locus notch homolog protein 1 OS=Cricetulus griseus GN=NOTCH1 PE=1 SV=2Swissprot2e-18
NOTC1_CRIGRNeurogenic locus notch homolog protein 1 OS=Cricetulus griseus GN=NOTCH1 PE=1 SV=2Swissprot3e-16
NOTC1_CRIGRNeurogenic locus notch homolog protein 1 OS=Cricetulus griseus GN=NOTCH1 PE=1 SV=2Swissprot7e-16
NOTC1_CRIGRNeurogenic locus notch homolog protein 1 OS=Cricetulus griseus GN=NOTCH1 PE=1 SV=2Swissprot5e-15
ENSP00000256646notch 2H.sapiens8e-62
FBpp0293201NotchH.sapiens6e-46
F02A9.6Caenorhabditis elegans Protein GLP-1 (glp-1) mRNA, complete cds.H.sapiens1e-45
FBpp0293201NotchH.sapiens4e-25
ENSP00000256646notch 2H.sapiens3e-22
SELECTED MOTIF SIMILARITIES
Comparison of cluster transcripts with INTERPRO. The alignments can suggest function of the cluster.

Identified MotifsDatabaseMax Score
PF00008.22|EGF|EGF-like domainPFAM1.1e-09
PF07974.8|EGF_2|EGF-like domainPFAM0.00064
PF13857.1|Ank_5|Ankyrin repeats (many copies)PFAM9.8e-06
PF13637.1|Ank_4|Ankyrin repeats (many copies)PFAM1.9e-09
PF00023.25|Ank|Ankyrin repeatPFAM5.2e-08
PF13606.1|Ank_3|Ankyrin repeatPFAM9.6e-06
PF00066.12|Notch|LNR domainPFAM5.1e-23
PF12796.2|Ank_2|Ankyrin repeats (3 copies)PFAM1.1e-11
Intramembrane polypeptide regionTMHMM0.05727
Cytoplasmic polypeptide regionTMHMM0.05727
Signal peptideSIGNALP0.826
TRANSCRIPTS
Amino acid translations of transcipts were clustered and used to generate a Smed Unigene. These transcripts are those that were clustered as well as other transcripts and sequences that have homology to the transcripts of the unigene cluster.

Transcript IDView Assembly AlignmentsTranscript Collection
Associated Gene Ontology Terms
Gene Ontology terms are derived from the unigene transcript cluster compared to InterPro proteins. The GO terms can suggest function of the cluster.

GO:0000139
Name Golgi membrane
Ontology Cellular component
Definition The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

GO:0001525
Name angiogenesis
Ontology Biological process
Synonymn
  • exact: blood vessel formation from pre-existing blood vessels
Definition Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

GO:0004872
Name receptor activity
Ontology Molecular function
Synonymn
  • alt_id: GO:0019041
  • narrow: receptor guanylate cyclase activity
  • narrow: viral antireceptor activity
Definition Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

GO:0005509
Name calcium ion binding
Ontology Molecular function
Synonymn
  • related: calcium ion storage activity
Definition Interacting selectively and non-covalently with calcium ions (Ca2+).

GO:0005634
Name nucleus
Ontology Cellular component
Synonymn
  • exact: cell nucleus
Definition A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

GO:0005796
Name Golgi lumen
Ontology Cellular component
Definition The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.

GO:0005886
Name plasma membrane
Ontology Cellular component
Synonymn
  • alt_id: GO:0005904
  • broad: juxtamembrane
  • exact: cell membrane
  • exact: cytoplasmic membrane
  • exact: plasmalemma
  • narrow: bacterial inner membrane
  • narrow: inner endospore membrane
  • narrow: plasma membrane lipid bilayer
Definition The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

GO:0006351
Name transcription, DNA-templated
Ontology Biological process
Synonymn
  • alt_id: GO:0006350
  • alt_id: GO:0061018
  • alt_id: GO:0061022
  • broad: cellular transcription
  • broad: transcription
  • exact: DNA-dependent transcription
  • exact: cellular transcription, DNA-dependent
  • exact: transcription, DNA-dependent
  • related: transcription regulator activity
Definition The cellular synthesis of RNA on a template of DNA.

GO:0006355
Name regulation of transcription, DNA-templated
Ontology Biological process
Synonymn
  • alt_id: GO:0032583
  • alt_id: GO:0045449
  • alt_id: GO:0061019
  • broad: transcriptional control
  • exact: regulation of cellular transcription, DNA-dependent
  • exact: regulation of transcription, DNA-dependent
  • related: regulation of gene-specific transcription
Definition Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

GO:0016021
Name integral to membrane
Ontology Cellular component
Synonymn
  • related: transmembrane
Definition Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

GO:0030154
Name cell differentiation
Ontology Biological process
Definition The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

GO:0050793
Name regulation of developmental process
Ontology Biological process
Definition Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

GO:0060271
Name cilium morphogenesis
Ontology Biological process
Synonymn
  • related: cilium organization
Definition A process that is carried out at the cellular level and in which the structure of a cilium is organized.

GO:0061314
Name Notch signaling involved in heart development
Ontology Biological process
Synonymn
  • exact: Notch signalling involved in heart development
Definition The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time.