Search Unigenes:
Smed Unigene SMU15036778 : Putative SLIT HOMOLOG 3

SMU15036778 is represented by 11 transcripts from 10 libraries.


Smed Unigenes are generated by clustering all available transcripts to generate a model, or Smed Unigene, representing all similar transcripts. The Smed Unigene may not accurately reflect each transcript due to biological processes such as alternative splicing.

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with ENSEMBL and SWISPROT proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms SpeciesSpecies or DBE-value
SLIT3_MOUSESlit homolog 3 protein OS=Mus musculus GN=Slit3 PE=2 SV=2Swissprot0.0
SLIT3_MOUSESlit homolog 3 protein OS=Mus musculus GN=Slit3 PE=2 SV=2Swissprot2e-52
FBpp0303574slitH.sapiens0.0
ENSP00000430333slit homolog 3 (Drosophila)H.sapiens0.0
F40E10.4Caenorhabditis elegans Protein SLT-1 (slt-1) mRNA, complete cds.H.sapiens0.0
ENSP00000430333slit homolog 3 (Drosophila)H.sapiens1e-52
ENSP00000430333slit homolog 3 (Drosophila)H.sapiens3e-52
ABC61956.2slit1 [Schmidtea mediterranea]NCBI-nr0.0
SELECTED MOTIF SIMILARITIES
Comparison of cluster transcripts with INTERPRO. The alignments can suggest function of the cluster.

Identified MotifsDatabaseMax Score
PF00560.28|LRR_1|Leucine Rich RepeatPFAM3.1e-23
PF12799.2|LRR_4|Leucine Rich repeats (2 copies)PFAM3.1e-39
PF00008.22|EGF|EGF-like domainPFAM2.7e-21
PF13855.1|LRR_8|Leucine rich repeatPFAM1.8e-81
PF01462.13|LRRNT|Leucine rich repeat N-terminal domainPFAM2.7e-08
PF14580.1|LRR_9|Leucine-rich repeatPFAM0.00046
Signal peptideSIGNALP0.723
PF00054.18|Laminin_G_1|Laminin G domainPFAM8.4e-16
PF02210.19|Laminin_G_2|Laminin G domainPFAM3.3e-17
TRANSCRIPTS
Amino acid translations of transcipts were clustered and used to generate a Smed Unigene. These transcripts are those that were clustered as well as other transcripts and sequences that have homology to the transcripts of the unigene cluster.

Transcript IDView Assembly AlignmentsTranscript Collection
GAKN01002749.1
TORONTO
comp63821_c0_seq1
SXLWT
comp67552_c0_seq1
ASXLREGEN
32069_c0s1
SRG12
smedV4_12111_0_1
DD
Smed_1.0.13501
OX
comp67814_c0_seq1
ASXLSORT
comp77354_c0_seq1
ASXLSORT
SMEDS2F2_00016471-RA
UNIQ
CUFF.176217.1
BERLIN
Contig34584
PN
Associated Gene Ontology Terms
Gene Ontology terms are derived from the unigene transcript cluster compared to InterPro proteins. The GO terms can suggest function of the cluster.

GO:0005102
Name receptor binding
Ontology Molecular function
Synonymn
  • narrow: receptor ligand
  • related: receptor-associated protein activity
Definition Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

GO:0005509
Name calcium ion binding
Ontology Molecular function
Synonymn
  • related: calcium ion storage activity
Definition Interacting selectively and non-covalently with calcium ions (Ca2+).

GO:0005615
Name extracellular space
Ontology Cellular component
Synonymn
  • related: intercellular space
Definition That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

GO:0007411
Name axon guidance
Ontology Biological process
Synonymn
  • alt_id: GO:0008040
  • exact: axon pathfinding
  • narrow: axon growth cone guidance
  • related: axon chemotaxis
Definition The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.

GO:0008285
Name negative regulation of cell proliferation
Ontology Biological process
Synonymn
  • exact: down regulation of cell proliferation
  • exact: down-regulation of cell proliferation
  • exact: downregulation of cell proliferation
  • narrow: inhibition of cell proliferation
Definition Any process that stops, prevents or reduces the rate or extent of cell proliferation.

GO:0009887
Name organ morphogenesis
Ontology Biological process
Synonymn
  • broad: histogenesis and organogenesis
Definition Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

GO:0010629
Name negative regulation of gene expression
Ontology Biological process
Definition Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

GO:0030308
Name negative regulation of cell growth
Ontology Biological process
Synonymn
  • exact: down regulation of cell growth
  • exact: down-regulation of cell growth
  • exact: downregulation of cell growth
  • narrow: inhibition of cell growth
Definition Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

GO:0032870
Name cellular response to hormone stimulus
Ontology Biological process
Definition Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.

GO:0035385
Name Roundabout signaling pathway
Ontology Biological process
Synonymn
  • exact: ROBO signaling pathway
  • exact: ROBO/SLIT signaling pathway
  • exact: Roundabout signalling pathway
Definition A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

GO:0048495
Name Roundabout binding
Ontology Molecular function
Synonymn
  • related: Roundabout receptor binding
Definition Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor.

GO:0048846
Name axon extension involved in axon guidance
Ontology Biological process
Definition The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues.

GO:0050919
Name negative chemotaxis
Ontology Biological process
Synonymn
  • exact: chemoaversion
  • exact: chemorepulsion
Definition The directed movement of a motile cell or organism towards a lower concentration of a chemical.

GO:0051414
Name response to cortisol
Ontology Biological process
Synonymn
  • exact: response to cortisol stimulus
  • exact: response to hydrocortisone stimulus
Definition Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.

GO:0061364
Name apoptotic process involved in luteolysis
Ontology Biological process
Synonymn
  • exact: structural luteolysis
  • narrow: apoptosis involved in luteolysis
Definition The apoptotic process that contributes to luteolysis.

GO:0070100
Name negative regulation of chemokine-mediated signaling pathway
Ontology Biological process
Synonymn
  • exact: negative regulation of chemokine-mediated signalling pathway
Definition Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor.