Search Unigenes:
Smed Unigene SMU15040087 : Cannot Determine

SMU15040087 is represented by 12 transcripts from 11 libraries.


Smed Unigenes are generated by clustering all available transcripts to generate a model, or Smed Unigene, representing all similar transcripts. The Smed Unigene may not accurately reflect each transcript due to biological processes such as alternative splicing.

SELECTED PROTEIN SIMILARITIES
Comparison of cluster transcripts with ENSEMBL and SWISPROT proteins. The alignments can suggest function of the cluster.

Best Hits and Hits from model organisms SpeciesSpecies or DBE-value
XP_009050162.1hypothetical protein LOTGIDRAFT_201339 [Lottia gigantea]NCBI-nr5e-179
FZD4_MOUSEFrizzled-4 OS=Mus musculus GN=Fzd4 PE=1 SV=1Swissprot9e-158
ENSP00000434034frizzled class receptor 4H.sapiens1e-157
FBpp0303135frizzledH.sapiens2e-100
Y71F9B.5a.2Caenorhabditis elegans Protein LIN-17, isoform a.H.sapiens2e-88
SELECTED MOTIF SIMILARITIES
Comparison of cluster transcripts with INTERPRO. The alignments can suggest function of the cluster.

Identified MotifsDatabaseMax Score
Intramembrane polypeptide regionTMHMM0.27677
Cytoplasmic polypeptide regionTMHMM0.27677
Non cytoplasmic polypeptide regionTMHMM0.27677
PF01392.17|Fz|Fz domainPFAM1.7e-26
Signal peptideSIGNALP0.715
PF01534.12|Frizzled|Frizzled/Smoothened family membrane regionPFAM1.8e-102
TRANSCRIPTS
Amino acid translations of transcipts were clustered and used to generate a Smed Unigene. These transcripts are those that were clustered as well as other transcripts and sequences that have homology to the transcripts of the unigene cluster.

Transcript IDView Assembly AlignmentsTranscript Collection
GAKN01015193.1
TORONTO
comp18892_c0_seq1
SXLWT
comp62320_c0_seq1
ASXLREGEN
43347_c0s1
SRG12
smedV4_7210_0_1
DD
c43096_g1_i1
SXLREGEN
Smed_1.0.00971
OX
comp57453_c0_seq1
ASXLSORT
SMEDS2F2_00022540-RA
UNIQ
KG_FZ-3
UNIQ
isotig23697
BERLIN
Contig48398
PN
Associated Gene Ontology Terms
Gene Ontology terms are derived from the unigene transcript cluster compared to InterPro proteins. The GO terms can suggest function of the cluster.

GO:0001553
Name luteinization
Ontology Biological process
Synonymn
  • related: luteal phase
Definition The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.

GO:0001568
Name blood vessel development
Ontology Biological process
Definition The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

GO:0001570
Name vasculogenesis
Ontology Biological process
Synonymn
  • exact: vascular morphogenesis
Definition The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.

GO:0004930
Name G-protein coupled receptor activity
Ontology Molecular function
Synonymn
  • alt_id: GO:0001622
  • alt_id: GO:0001623
  • alt_id: GO:0001624
  • alt_id: GO:0001625
  • alt_id: GO:0016526
  • exact: G protein coupled receptor activity
  • exact: G protein linked receptor activity
  • exact: G-protein linked receptor activity
  • exact: G-protein-coupled receptor activity
  • exact: GPCR activity
  • exact: ligand-dependent GPCR activity
  • exact: receptor activity, G-protein coupled
  • narrow: EBV-induced receptor
  • narrow: Epstein-Barr Virus-induced receptor activity
  • narrow: G-protein coupled receptor activity, unknown ligand
  • narrow: Mas proto-oncogene receptor activity
  • narrow: RDC1 receptor activity
  • narrow: SREB receptor
  • narrow: orphan G protein coupled receptor activity
  • narrow: orphan G-protein coupled receptor activity
  • narrow: orphan GPCR activity
  • narrow: super conserved receptor expressed in brain receptor activity
Definition Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

GO:0005886
Name plasma membrane
Ontology Cellular component
Synonymn
  • alt_id: GO:0005904
  • broad: juxtamembrane
  • exact: cell membrane
  • exact: cytoplasmic membrane
  • exact: plasmalemma
  • narrow: bacterial inner membrane
  • narrow: inner endospore membrane
  • narrow: plasma membrane lipid bilayer
Definition The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

GO:0005911
Name cell-cell junction
Ontology Cellular component
Synonymn
  • exact: intercellular junction
Definition A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals.

GO:0007223
Name Wnt signaling pathway, calcium modulating pathway
Ontology Biological process
Synonymn
  • exact: Wnt receptor signaling pathway, calcium modulating pathway
  • exact: Wnt-activated signaling pathway, calcium modulating pathway
  • narrow: frizzled-2 signaling pathway
  • narrow: frizzled-2 signalling pathway
  • related: non-canonical Wnt signaling pathway
Definition The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).

GO:0007605
Name sensory perception of sound
Ontology Biological process
Synonymn
  • exact: hearing
  • exact: perception of sound
Definition The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.

GO:0009986
Name cell surface
Ontology Cellular component
Synonymn
  • alt_id: GO:0009928
  • alt_id: GO:0009929
  • exact: cell associated
  • exact: cell bound
Definition The external part of the cell wall and/or plasma membrane.

GO:0010812
Name negative regulation of cell-substrate adhesion
Ontology Biological process
Definition Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.

GO:0016021
Name integral to membrane
Ontology Cellular component
Synonymn
  • related: transmembrane
Definition Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

GO:0016055
Name Wnt signaling pathway
Ontology Biological process
Synonymn
  • alt_id: GO:0007222
  • exact: Wg signaling pathway
  • exact: Wg signalling pathway
  • exact: Wingless signaling pathway
  • exact: Wingless signalling pathway
  • exact: Wnt receptor signaling pathway
  • exact: Wnt receptor signalling pathway
  • exact: frizzled signaling pathway
  • exact: frizzled signalling pathway
  • related: Wnt-activated signaling pathway
Definition The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

GO:0017147
Name Wnt-protein binding
Ontology Molecular function
Definition Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.

GO:0019955
Name cytokine binding
Ontology Molecular function
Synonymn
  • alt_id: GO:0019965
  • narrow: IL binding
  • narrow: interleukin binding
Definition Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

GO:0030165
Name PDZ domain binding
Ontology Molecular function
Synonymn
  • exact: DHR-domain binding
  • exact: GLGF-domain binding
Definition Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.

GO:0030947
Name regulation of vascular endothelial growth factor receptor signaling pathway
Ontology Biological process
Synonymn
  • exact: regulation of VEGF receptor signaling pathway
  • exact: regulation of VEGF receptor signalling pathway
  • exact: regulation of vascular endothelial growth factor receptor signalling pathway
Definition Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.

GO:0031625
Name ubiquitin protein ligase binding
Ontology Molecular function
Synonymn
  • exact: ubiquitin ligase binding
Definition Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.

GO:0031987
Name locomotion involved in locomotory behavior
Ontology Biological process
Synonymn
  • exact: locomotion during locomotory behaviour
Definition Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.

GO:0034446
Name substrate adhesion-dependent cell spreading
Ontology Biological process
Synonymn
  • exact: cell spreading during cell substrate adhesion
  • exact: substrate adhesion dependent cell spreading
Definition The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

GO:0035426
Name extracellular matrix-cell signaling
Ontology Biological process
Synonymn
  • exact: cell-extracellular matrix signalling
  • exact: extracellular matrix-cell signalling
Definition Any process that mediates the transfer of information between the extracellular matrix and a cell.

GO:0035567
Name non-canonical Wnt signaling pathway
Ontology Biological process
Synonymn
  • exact: beta-catenin-independent Wnt receptor signaling pathway
  • exact: non-canonical Wnt receptor signaling pathway
  • exact: non-canonical Wnt receptor signalling pathway
  • exact: non-canonical Wnt-activated signaling pathway
Definition The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.

GO:0042701
Name progesterone secretion
Ontology Biological process
Definition The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta.

GO:0042803
Name protein homodimerization activity
Ontology Molecular function
Synonymn
  • broad: dimerization activity
Definition Interacting selectively and non-covalently with an identical protein to form a homodimer.

GO:0042813
Name Wnt-activated receptor activity
Ontology Molecular function
Synonymn
  • exact: Wnt receptor activity
  • related: frizzled receptor activity
  • related: frizzled-2 receptor activity
Definition Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.

GO:0043507
Name positive regulation of JUN kinase activity
Ontology Biological process
Synonymn
  • exact: positive regulation of JUNK activity
  • exact: up regulation of JNK activity
  • exact: up-regulation of JNK activity
  • exact: upregulation of JNK activity
  • narrow: stimulation of JNK activity
Definition Any process that activates or increases the frequency, rate or extent of JUN kinase activity.

GO:0045893
Name positive regulation of transcription, DNA-templated
Ontology Biological process
Synonymn
  • alt_id: GO:0043193
  • alt_id: GO:0045941
  • alt_id: GO:0061020
  • exact: positive regulation of cellular transcription, DNA-dependent
  • exact: positive regulation of transcription, DNA-dependent
  • exact: up regulation of transcription, DNA-dependent
  • exact: up-regulation of transcription, DNA-dependent
  • exact: upregulation of transcription, DNA-dependent
  • narrow: activation of transcription, DNA-dependent
  • narrow: stimulation of gene-specific transcription
  • narrow: stimulation of transcription, DNA-dependent
  • related: activation of gene-specific transcription
  • related: positive regulation of gene-specific transcription
  • related: transcription activator activity
  • related: up regulation of gene-specific transcription
  • related: up-regulation of gene-specific transcription
  • related: upregulation of gene-specific transcription
Definition Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

GO:0046982
Name protein heterodimerization activity
Ontology Molecular function
Definition Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.

GO:0051091
Name positive regulation of sequence-specific DNA binding transcription factor activity
Ontology Biological process
Synonymn
  • broad: positive regulation of transcription factor activity
  • exact: up regulation of transcription factor activity
  • exact: up-regulation of transcription factor activity
  • exact: upregulation of transcription factor activity
  • narrow: activation of transcription factor activity
  • narrow: stimulation of transcription factor activity
Definition Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

GO:0060070
Name canonical Wnt signaling pathway
Ontology Biological process
Synonymn
  • exact: Wnt receptor signaling pathway through beta-catenin
  • exact: Wnt receptor signaling pathway via beta-catenin
  • exact: Wnt receptor signalling pathway through beta-catenin
  • exact: canonical Wnt receptor signaling pathway
  • exact: canonical Wnt-activated signaling pathway
  • narrow: frizzled-1 receptor signaling pathway
Definition The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.

GO:0061299
Name retina vasculature morphogenesis in camera-type eye
Ontology Biological process
Synonymn
  • exact: retinal vasculature morphogenesis
Definition The process in which the vasculature of the retina is generated and organized.

GO:0061301
Name cerebellum vasculature morphogenesis
Ontology Biological process
Definition The process in which the vasculature of the cerebellum is generated and organized.

GO:0061304
Name retinal blood vessel morphogenesis
Ontology Biological process
Definition The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure.

GO:0070062
Name extracellular vesicular exosome
Ontology Cellular component
Definition A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.